4ECE

Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine

Summary for 4ECE

Entry DOI	10.2210/pdb4ece/pdb
Related	4EAR 4EB8
Descriptor	Purine nucleoside phosphorylase, GUANINE (3 entities in total)
Functional Keywords	transferase, pnp, guanine, purine nucleoside phosphorylase, nucleoside binding, purine base binding, purine-nucleoside phosphorylase activity, drug binding, transferring glycosyl groups, phosphate ion binding, intracellular, cytosol
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton (By similarity): P00491
Total number of polymer chains	6
Total formula weight	217669.53
Authors	Haapalainen, A.M.,Ho, M.C.,Suarez, J.J.,Almo, S.C.,Schramm, V.L. (deposition date: 2012-03-26, release date: 2013-02-06, Last modification date: 2024-02-28)
Primary citation	Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol., 20:212-222, 2013 Cited by PubMed: 23438750 DOI: 10.1016/j.chembiol.2013.01.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation