4EC2

Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous

Summary for 4EC2

Entry DOI	10.2210/pdb4ec2/pdb
Related	2FQL 3OEQ 3OER
Descriptor	Frataxin homolog, mitochondrial, FE (II) ION (2 entities in total)
Functional Keywords	alpha/beta sandwich, metallochaperone, iron-storage, transport protein
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Mitochondrion matrix : Q07540
Total number of polymer chains	1
Total formula weight	13727.03
Authors	Soderberg, C.A.G.,Rajan, S.,Gakh, O.,Isaya, G.,Al-Karadaghi, S. (deposition date: 2012-03-26, release date: 2013-01-30, Last modification date: 2023-09-13)
Primary citation	Soderberg, C.A.,Rajan, S.,Shkumatov, A.V.,Gakh, O.,Schaefer, S.,Ahlgren, E.C.,Svergun, D.I.,Isaya, G.,Al-Karadaghi, S. The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization. J.Biol.Chem., 288:8156-8167, 2013 Cited by PubMed: 23344952 DOI: 10.1074/jbc.M112.442285 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.002 Å)

Structure validation