4EAJ

Co-crystal of AMPK core with AMP soaked with ATP

Summary for 4EAJ

Entry DOI	10.2210/pdb4eaj/pdb
Related	4EAG 4EAI 4EAK 4EAL
Descriptor	5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... (6 entities in total)
Functional Keywords	ampk, transferase
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasm : P54645
Total number of polymer chains	3
Total formula weight	60780.21
Authors	Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. (deposition date: 2012-03-22, release date: 2012-06-06, Last modification date: 2023-11-08)
Primary citation	Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19:716-718, 2012 Cited by PubMed: 22659875 DOI: 10.1038/nsmb.2319 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.609 Å)

Structure validation