4E1Z

Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

Summary for 4E1Z

• Entry DOI: 10.2210/pdb4e1z/pdb
• Related: 4E20
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]furan-2-carboxamide (3 entities in total)
• Functional Keywords: kinase catalytic domain, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 1
• Total formula weight: 34189.47

Authors

Argiriadi, M.A.,Talanian, R.V.,Borhani, D.W. (deposition date: 2012-03-07, release date: 2012-10-03, Last modification date: 2024-02-28)

• Primary citation: Argiriadi, M.A.,Goedken, E.R.,Banach, D.,Borhani, D.W.,Burchat, A.,Dixon, R.W.,Marcotte, D.,Overmeyer, G.,Pivorunas, V.,Sadhukhan, R.,Sousa, S.,Moore, N.S.,Tomlinson, M.,Voss, J.,Wang, L.,Wishart, N.,Woller, K.,Talanian, R.V.; Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.; Bmc Struct.Biol., 12:22-22, 2012; PubMed: 22995073; DOI: 10.1186/1472-6807-12-22

Experimental method

X-RAY DIFFRACTION (2.5 Å)