4E0N

SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II)

Summary for 4E0N

Entry DOI	10.2210/pdb4e0n/pdb
Related	4E0K 4E0L 4E0M 4E0O
Descriptor	Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
Functional Keywords	amyloid, out-of-register, fiber-forming, macrocycle, protein fibril
Total number of polymer chains	4
Total formula weight	8817.00
Authors	Zhao, M.,Liu, C.,Michael, S.R.,Eisenberg, D. (deposition date: 2012-03-04, release date: 2012-12-19, Last modification date: 2023-11-15)
Primary citation	Liu, C.,Zhao, M.,Jiang, L.,Cheng, P.N.,Park, J.,Sawaya, M.R.,Pensalfini, A.,Gou, D.,Berk, A.J.,Glabe, C.G.,Nowick, J.,Eisenberg, D. Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109:20913-20918, 2012 Cited by PubMed: 23213214 DOI: 10.1073/pnas.1218792109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation