4DX1

Crystal structure of the human TRPV4 ankyrin repeat domain

Summary for 4DX1

Entry DOI	10.2210/pdb4dx1/pdb
Related	4DX2
Descriptor	Transient receptor potential cation channel subfamily V member 4, PHOSPHATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	ankyrin repeat, ion channel, menbrane, transport protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Multi-pass membrane protein (By similarity). Isoform 1: Cell membrane. Isoform 5: Cell membrane: Q9HBA0
Total number of polymer chains	2
Total formula weight	59480.44
Authors	Inada, H.,Gaudet, R. (deposition date: 2012-02-27, release date: 2012-07-18, Last modification date: 2024-02-28)
Primary citation	Inada, H.,Procko, E.,Sotomayor, M.,Gaudet, R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51:6195-6206, 2012 Cited by PubMed: 22702953 DOI: 10.1021/bi300279b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation