4DVQ
Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone
Summary for 4DVQ
Entry DOI | 10.2210/pdb4dvq/pdb |
Descriptor | Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, DESOXYCORTICOSTERONE, ... (5 entities in total) |
Functional Keywords | cytochrome p450, cyp11b2, aldosterone synthase, monooxygenase, heme protein, mineralocorticoid, corticosteroid, mitochondria, membrane, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion membrane: P19099 |
Total number of polymer chains | 12 |
Total formula weight | 680021.94 |
Authors | Strushkevich, N.,Shen, L.,Tempel, W.,Arrowsmith, C.,Edwards, A.,Usanov, S.A.,Park, H.-W. (deposition date: 2012-02-23, release date: 2013-01-30, Last modification date: 2024-02-28) |
Primary citation | Strushkevich, N.,Gilep, A.A.,Shen, L.,Arrowsmith, C.H.,Edwards, A.M.,Usanov, S.A.,Park, H.W. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Mol.Endocrinol., 27:315-324, 2013 Cited by PubMed: 23322723DOI: 10.1210/me.2012-1287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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