4DT7

Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C

Summary for 4DT7

Entry DOI	10.2210/pdb4dt7/pdb
Related	1SHH
Descriptor	Thrombin light chain, Thrombin heavy chain, Vitamin K-dependent protein C, ... (7 entities in total)
Functional Keywords	serine protease, hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734
Total number of polymer chains	6
Total formula weight	71847.96
Authors	Pozzi, N.,Barranco-Medina, S.,Chen, Z.,Di Cera, E. (deposition date: 2012-02-20, release date: 2012-05-09, Last modification date: 2023-09-13)
Primary citation	Pozzi, N.,Barranco-Medina, S.,Chen, Z.,Di Cera, E. Exposure of R169 controls protein C activation and autoactivation. Blood, 120:664-670, 2012 Cited by PubMed: 22535660 DOI: 10.1182/blood-2012-03-415323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation