4DRQ

Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-1-((S)-1-(3,5-dichlorophenylsulfonyl)piperidine-2-carbonyloxy)-3-(3,4-dimethoxy -phenyl)propyl)phenoxy)acetic acid

Summary for 4DRQ

Entry DOI	10.2210/pdb4drq/pdb
Related	4DRK 4DRM 4DRN 4DRo 4DRp
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1S)-1-[({(2S)-1-[(3,5-dichlorophenyl)sulfonyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetic acid (3 entities in total)
Functional Keywords	fk-506 binding domain, hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, isomerase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q13451
Total number of polymer chains	1
Total formula weight	14692.64
Authors	Gopalakrishnan, R.,Kozany, C.,Wang, Y.,Hoogeland, B.,Bracher, A.,Hausch, F.,Schneider, S. (deposition date: 2012-02-17, release date: 2012-04-18, Last modification date: 2023-09-13)
Primary citation	Gopalakrishnan, R.,Kozany, C.,Wang, Y.,Schneider, S.,Hoogeland, B.,Bracher, A.,Hausch, F. Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52. J.Med.Chem., 55:4123-4131, 2012 Cited by PubMed: 22455398 DOI: 10.1021/jm201747c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation