4DQY

Structure of Human PARP-1 bound to a DNA double strand break

Summary for 4DQY

• Entry DOI: 10.2210/pdb4dqy/pdb
• Descriptor: Poly [ADP-ribose] polymerase 1, DNA (26-MER), ZINC ION, ... (6 entities in total)
• Functional Keywords: parp, poly(adp-ribose) polymerase, dna binding protein, adp-ribosyl transferase, parp-like zinc finger, poly(adp-ribosyl)ation, dna damage detection, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P09874 P09874 P09874
• Total number of polymer chains: 8
• Total formula weight: 193570.52

Authors

Langelier, M.F.,Pascal, J.M. (deposition date: 2012-02-16, release date: 2012-05-30, Last modification date: 2024-02-28)

• Primary citation: Langelier, M.F.,Planck, J.L.,Roy, S.,Pascal, J.M.; Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.; Science, 336:728-732, 2012; PubMed: 22582261; DOI: 10.1126/science.1216338

Experimental method

X-RAY DIFFRACTION (3.25 Å)