4DO4

Pharmacological chaperones for human alpha-N-acetylgalactosaminidase

Summary for 4DO4

Entry DOI	10.2210/pdb4do4/pdb
Related	3H53 3H54 3H55 3IGU 4DO5 4DO6
Descriptor	Alpha-N-acetylgalactosaminidase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	pharmacological chaperone, (beta/alpha)8 barrel, glycosidase, carbohydrate-binding protein, glycoprotein, lysosome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P17050
Total number of polymer chains	2
Total formula weight	96636.85
Authors	Clark, N.E.,Garman, S.C. (deposition date: 2012-02-09, release date: 2012-10-10, Last modification date: 2023-09-13)
Primary citation	Clark, N.E.,Metcalf, M.C.,Best, D.,Fleet, G.W.,Garman, S.C. Pharmacological chaperones for human alpha-N-acetylgalactosaminidase Proc.Natl.Acad.Sci.USA, 109:17400-17405, 2012 Cited by PubMed: 23045655 DOI: 10.1073/pnas.1203924109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation