4DMA

Crystal structure of ERa LBD in complex with RU100132

Summary for 4DMA

Entry DOI	10.2210/pdb4dma/pdb
Related	1G50 4DM6 4DM8
Descriptor	Estrogen receptor, Nuclear receptor coactivator 1, 2'-bromo-6'-(furan-3-yl)-4'-(hydroxymethyl)biphenyl-4-ol, ... (4 entities in total)
Functional Keywords	transcription, nuclear receptor, er, estrogen receptor, alpha helical sandwich, transcription factor, estradiol, transcription-protein binding-agonist complex, transcription/protein binding/agonist
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	60709.04
Authors	Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. (deposition date: 2012-02-07, release date: 2012-03-07, Last modification date: 2024-02-28)
Primary citation	Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors. Proc.Natl.Acad.Sci.USA, 109:E588-E594, 2012 Cited by PubMed: 22355136 DOI: 10.1073/pnas.1118192109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation