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4DLI

Human p38 MAP kinase in complex with RL87

Summary for 4DLI
Entry DOI10.2210/pdb4dli/pdb
Related4DLJ
DescriptorMitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine (3 entities in total)
Functional Keywordsmap kinase insert, transferase, lipid binding pocket, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q16539
Total number of polymer chains1
Total formula weight41821.73
Authors
Gruetter, C.,Getlik, M.,Simard, J.R.,Rauh, D. (deposition date: 2012-02-06, release date: 2013-01-23, Last modification date: 2023-09-13)
Primary citationGetlik, M.,Simard, J.R.,Termathe, M.,Grutter, C.,Rabiller, M.,van Otterlo, W.A.,Rauh, D.
Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38alpha kinase.
Plos One, 7:e39713-e39713, 2012
Cited by
PubMed: 22768308
DOI: 10.1371/journal.pone.0039713
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

217705

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