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4DHQ

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening

Summary for 4DHQ
Entry DOI10.2210/pdb4dhq/pdb
Related3T0L 3T0M 3U9X 4DHM 4DHN 4DHO 4DHP 4DHR 4DHS 4DHT 4DHU
Descriptor14-3-3 protein sigma, MAGNESIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsadapter protein, phosphoprotein binding, protein binding-inhibitor complex, protein binding/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P31947
Total number of polymer chains1
Total formula weight27128.07
Authors
Thiel, P.,Roeglin, L.,Kohlbacher, O.,Ottmann, C. (deposition date: 2012-01-30, release date: 2013-07-31, Last modification date: 2013-09-04)
Primary citationThiel, P.,Roglin, L.,Meissner, N.,Hennig, S.,Kohlbacher, O.,Ottmann, C.
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49:8468-8470, 2013
Cited by
PubMed: 23939230
DOI: 10.1039/c3cc44612c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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