4DFL

Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor

Summary for 4DFL

Entry DOI	10.2210/pdb4dfl/pdb
Related	4DFN
Descriptor	Tyrosine-protein kinase SYK, 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	syk, transferase, kinase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane : P43405
Total number of polymer chains	1
Total formula weight	32361.29
Authors	Lopez, M.,Segarra, V.,Vidal, B.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M.,Nagel, S.,Schreiner, P. (deposition date: 2012-01-24, release date: 2012-04-25, Last modification date: 2024-02-28)
Primary citation	Forns, P.,Esteve, C.,Taboada, L.,Alonso, J.A.,Orellana, A.,Maldonado, M.,Carreno, C.,Ramis, I.,Lopez, M.,Miralpeix, M.,Vidal, B. Pyrazine-based Syk kinase inhibitors. Bioorg.Med.Chem.Lett., 22:2784-2788, 2012 Cited by PubMed: 22425453 DOI: 10.1016/j.bmcl.2012.02.087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation