4DCH

Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations

Summary for 4DCH

Entry DOI	10.2210/pdb4dch/pdb
Descriptor	Glucokinase, alpha-D-glucopyranose, (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide, ... (5 entities in total)
Functional Keywords	gk beta cell, small molecule, open conformation, kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	54142.03
Authors	Greasley, S.E.,Hickey, M.,Feng, J.,Garcia, E. (deposition date: 2012-01-17, release date: 2012-02-08, Last modification date: 2024-02-28)
Primary citation	Liu, S.,Ammirati, M.J.,Song, X.,Knafels, J.D.,Zhang, J.,Greasley, S.E.,Pfefferkorn, J.A.,Qiu, X. Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287:13598-13610, 2012 Cited by PubMed: 22298776 DOI: 10.1074/jbc.M111.274126 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation