4DAJ

Structure of the M3 Muscarinic Acetylcholine Receptor

Summary for 4DAJ

• Entry DOI: 10.2210/pdb4daj/pdb
• Descriptor: Muscarinic acetylcholine receptor M3, Lysozyme, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, PHOSPHATE ION (3 entities in total)
• Functional Keywords: g protein-coupled receptor, muscarinic receptor, acetylcholine receptor, signaling protein, hydrolase
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P08483
• Total number of polymer chains: 4
• Total formula weight: 222480.95

Authors

Kruse, A.C.,Hu, J.,Pan, A.C.,Arlow, D.H.,Rosenbaum, D.M.,Rosemond, E.,Green, H.F.,Liu, T.,Chae, P.S.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Wess, J.,Kobilka, B. (deposition date: 2012-01-12, release date: 2012-02-22, Last modification date: 2023-09-13)

• Primary citation: Kruse, A.C.,Hu, J.,Pan, A.C.,Arlow, D.H.,Rosenbaum, D.M.,Rosemond, E.,Green, H.F.,Liu, T.,Chae, P.S.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Wess, J.,Kobilka, B.K.; Structure and dynamics of the M3 muscarinic acetylcholine receptor.; Nature, 482:552-556, 2012; PubMed: 22358844; DOI: 10.1038/nature10867

Experimental method

X-RAY DIFFRACTION (3.4 Å)