4D9T

Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate

Summary for 4D9T

• Entry DOI: 10.2210/pdb4d9t/pdb
• Related: 4D9U
• Descriptor: Ribosomal protein S6 kinase alpha-3, methyl (2S)-3-{4-amino-7-[(1E)-3-hydroxyprop-1-en-1-yl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-2-cyanopropanoate, SODIUM ION, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, reversible, thiol, phosphorylation, migration, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): P51812
• Total number of polymer chains: 1
• Total formula weight: 38893.34

Authors

Serafimova, I.M.,Pufall, M.A.,Krishnan, S.,Duda, K.,Cohen, M.S.,Maglathlin, R.L.,McFarland, J.M.,Miller, R.M.,Frodin, M.,Taunton, J. (deposition date: 2012-01-12, release date: 2012-04-25, Last modification date: 2012-05-16)

• Primary citation: Serafimova, I.M.,Pufall, M.A.,Krishnan, S.,Duda, K.,Cohen, M.S.,Maglathlin, R.L.,McFarland, J.M.,Miller, R.M.,Frodin, M.,Taunton, J.; Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.; Nat.Chem.Biol., 8:471-476, 2012; PubMed: 22466421; DOI: 10.1038/nchembio.925

Experimental method

X-RAY DIFFRACTION (2.4 Å)