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4D72

Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A L19 mutant)

Summary for 4D72
Entry DOI10.2210/pdb4d72/pdb
Related4D71
Related PRD IDPRD_900036
DescriptorGLYCOSIDE HYDROLASE, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (5 entities in total)
Functional Keywordshydrolase, blood group antigen
Biological sourceSTREPTOCOCCUS PNEUMONIAE
Total number of polymer chains1
Total formula weight69555.99
Authors
Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. (deposition date: 2014-11-19, release date: 2015-01-21, Last modification date: 2023-12-20)
Primary citationKwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Koetzler, M.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G.
Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution.
J.Am.Chem.Soc., 137:5695-, 2015
Cited by
PubMed: 25870881
DOI: 10.1021/JA5116088
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.11 Å)
Structure validation

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