4D71

Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A X02 mutant)

Summary for 4D71

Entry DOI	10.2210/pdb4d71/pdb
Related	4D72
Descriptor	GLYCOSIDE HYDROLASE, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	hydrolase, blood group antigen
Biological source	STREPTOCOCCUS PNEUMONIAE
Total number of polymer chains	1
Total formula weight	69885.18
Authors	Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. (deposition date: 2014-11-19, release date: 2015-01-21, Last modification date: 2023-12-20)
Primary citation	Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Koetzler, M.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution. J.Am.Chem.Soc., 137:5695-, 2015 Cited by PubMed: 25870881 DOI: 10.1021/JA5116088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation