4D0T

GalNAc-T2 crystal soaked with UDP-GalNAc, EA2 peptide and manganese

Summary for 4D0T

• Entry DOI: 10.2210/pdb4d0t/pdb
• Related: 4D0Z 4D11
• Descriptor: POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, PEPTIDE, MANGANESE (II) ION, ... (8 entities in total)
• Functional Keywords: transferase, retaining galnac-t2, substrate-guided sni-type reaction, qm/mm metadynamics, bi-bi kinetic mechanism, substrate specificity, protein x-ray crystallography, acetamido group
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 8
• Total formula weight: 395138.27

Authors

Lira-Navarrete, E.,Iglesias-Fernandez, J.,Zandberg, W.F.,Companon, I.,Kong, Y.,Corzana, F.,Pinto, B.M.,Clausen, H.,Peregrina, J.M.,Vocadlo, D.,Rovira, C.,Hurtado-Guerrero, R. (deposition date: 2014-04-30, release date: 2014-05-28, Last modification date: 2023-12-20)

• Primary citation: Lira-Navarrete, E.,Iglesias-Fernandez, J.,Zandberg, W.F.,Companon, I.,Kong, Y.,Corzana, F.,Pinto, B.M.,Clausen, H.,Peregrina, J.M.,Vocadlo, D.,Rovira, C.,Hurtado-Guerrero, R.; Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.; Angew.Chem.Int.Ed.Engl., 53:8206-, 2014; PubMed: 24954443; DOI: 10.1002/ANIE.201402781

Experimental method

X-RAY DIFFRACTION (2.45 Å)