4CQO

Structure of the human CNOT1 superfamily homology domain in complex with a Nanos1 peptide

Summary for 4CQO

Entry DOI	10.2210/pdb4cqo/pdb
Descriptor	CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, NANOS HOMOLOG 1 (3 entities in total)
Functional Keywords	gene regulation, translation, deadenylation, translational repression, protein complex, development, short linear motif
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm, P-body: A5YKK6 Cytoplasm, perinuclear region: Q8WY41
Total number of polymer chains	4
Total formula weight	126892.52
Authors	Raisch, T.,Jonas, S.,Weichenrieder, O.,Bhandari, D.,Izaurralde, E. (deposition date: 2014-02-21, release date: 2014-04-23, Last modification date: 2023-12-20)
Primary citation	Bhandari, D.,Raisch, T.,Weichenrieder, O.,Jonas, S.,Izaurralde, E. Structural Basis for the Nanos-Mediated Recruitment of the Ccr4-not Complex and Translational Repression Genes Dev., 28:888-, 2014 Cited by PubMed: 24736845 DOI: 10.1101/GAD.237289.113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation