4CQ8

Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178

Summary for 4CQ8

Entry DOI	10.2210/pdb4cq8/pdb
Related	4CQ9 4CQA
Descriptor	DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase, dhodh
Biological source	PLASMODIUM FALCIPARUM
Total number of polymer chains	2
Total formula weight	92641.48
Authors	Rowland, P. (deposition date: 2014-02-12, release date: 2014-04-30, Last modification date: 2019-05-08)
Primary citation	Ross, L.S.,Javier Gamo, F.,Lafuente-Monasterio, M.J.E.,Singh, O.M.P.,Rowland, P.,Wiegand, R.C.,Wirth, D.F. In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289:17980-, 2014 Cited by PubMed: 24782313 DOI: 10.1074/JBC.M114.558353 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation