4COS

Crystal structure of the PHD-Bromo-PWWP cassette of human PRKCBP1

Summary for 4COS

Entry DOI	10.2210/pdb4cos/pdb
Descriptor	PROTEIN KINASE C-BINDING PROTEIN 1, ZINC ION, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
Functional Keywords	transcription, phd domain, bromo domain, pwwp domain
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9ULU4
Total number of polymer chains	1
Total formula weight	38206.17
Authors	Krojer, T.,Savitsky, P.,Newman, J.A.,Cooper, C.D.O.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Filippakopoulos, P. (deposition date: 2014-01-30, release date: 2014-03-05, Last modification date: 2018-01-24)
Primary citation	Savitsky, P.,Krojer, T.,Fujisawa, T.,Lambert, J.P.,Picaud, S.,Wang, C.Y.,Shanle, E.K.,Krajewski, K.,Friedrichsen, H.,Kanapin, A.,Goding, C.,Schapira, M.,Samsonova, A.,Strahl, B.D.,Gingras, A.C.,Filippakopoulos, P. Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Cell Rep, 17:2724-2737, 2016 Cited by PubMed: 27926874 DOI: 10.1016/j.celrep.2016.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation