4CLA

ALTERNATIVE BINDING MODES FOR CHLORAMPHENICOL AND 1-SUBSTITUTED CHLORAMPHENICOL ANALOGUES REVEALED BY SITE-DIRECTED MUTAGENESIS AND X-RAY CRYSTALLOGRAPHY OF CHLORAMPHENICOL ACETYLTRANSFERASE

Summary for 4CLA

Entry DOI	10.2210/pdb4cla/pdb
Descriptor	TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, CHLORAMPHENICOL, ... (4 entities in total)
Functional Keywords	transferase (acyltransferase)
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	25496.51
Authors	Leslie, A.G.W. (deposition date: 1990-10-23, release date: 1992-01-15, Last modification date: 2024-02-28)
Primary citation	Murray, I.A.,Lewendon, A.,Williams, J.A.,Cullis, P.M.,Shaw, W.V. Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase. Biochemistry, 30:3763-3770, 1991 Cited by PubMed: 2015231 DOI: 10.1021/bi00229a025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation