4CL9

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH I-BET295

Summary for 4CL9

• Entry DOI: 10.2210/pdb4cl9/pdb
• Related: 4CLB
• Descriptor: BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, propan-2-yl N-[(2S,4R)-1-ethanoyl-2-methyl-6-[4-[[8-(oxidanylamino)-8-oxidanylidene-octanoyl]amino]phenyl]-3,4-dihydro-2H-quinolin-4-yl]carbamate, ... (4 entities in total)
• Functional Keywords: transcription, inhibitor, histone, epigenetic reader, antagonist
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15714.11

Authors

Chung, C.,Atkinson, S. (deposition date: 2014-01-13, release date: 2014-12-24, Last modification date: 2018-05-16)

• Primary citation: Atkinson, S.J.,Soden, P.E.,Angell, D.C.,Bantscheff, M.,Chung, C.,Giblin, K.A.,Smithers, N.,Furze, R.C.,Gordon, L.,Drewes, G.,Rioja, I.,Witherington, J.,Parr, N.J.,Prinjha, R.K.; The Structure Based Design of Dual Hdac/Bet Inhibitors as Novel Epigenetic Probes.; Medchemcomm, 5:342-, 2014; DOI: 10.1039/C3MD00285C

Experimental method

X-RAY DIFFRACTION (1.4 Å)