4CI3

Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide

Summary for 4CI3

Entry DOI	10.2210/pdb4ci3/pdb
Related	2B5L 2B5M 3E0C 3EI1 3EI2 3EI3 3EI4 4A11 4CI1 4CI2
Descriptor	DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ZINC ION, ... (4 entities in total)
Functional Keywords	dna binding protein, ddb1, crbn, cullin, e3 ligase, ubiquitin, thalidomide, contergan
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	183559.73
Authors	Fischer, E.S.,Boehm, K.,Thoma, N.H. (deposition date: 2013-12-05, release date: 2014-07-16, Last modification date: 2023-12-20)
Primary citation	Fischer, E.S.,Bohm, K.,Lydeard, J.R.,Yang, H.,Stadler, M.B.,Cavadini, S.,Nagel, J.,Serluca, F.,Acker, V.,Lingaraju, G.M.,Tichkule, R.B.,Schebesta, M.,Forrester, W.C.,Schirle, M.,Hassiepen, U.,Ottl, J.,Hild, M.,Beckwith, R.E.J.,Harper, J.W.,Jenkins, J.L.,Thoma, N.H. Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512:49-, 2014 Cited by PubMed: 25043012 DOI: 10.1038/NATURE13527 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation