4CI1

Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide

Summary for 4CI1

• Entry DOI: 10.2210/pdb4ci1/pdb
• Related: 4CI2 4CI3
• Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ZINC ION, ... (5 entities in total)
• Functional Keywords: dna binding protein-protein complex, dna binding protein-protein binding complex, ubiquitin, cont, dna binding protein/protein
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 184024.64

Authors

Fischer, E.S.,Boehm, K.,Thoma, N.H. (deposition date: 2013-12-05, release date: 2014-07-16, Last modification date: 2019-04-03)

• Primary citation: Fischer, E.S.,Bohm, K.,Lydeard, J.R.,Yang, H.,Stadler, M.B.,Cavadini, S.,Nagel, J.,Serluca, F.,Acker, V.,Lingaraju, G.M.,Tichkule, R.B.,Schebesta, M.,Forrester, W.C.,Schirle, M.,Hassiepen, U.,Ottl, J.,Hild, M.,Beckwith, R.E.J.,Harper, J.W.,Jenkins, J.L.,Thoma, N.H.; Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.; Nature, 512:49-, 2014; PubMed: 25043012; DOI: 10.1038/NATURE13527

Experimental method

X-RAY DIFFRACTION (2.98 Å)