4CH9

Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide

Summary for 4CH9

Entry DOI	10.2210/pdb4ch9/pdb
Related	4CHB
Descriptor	KELCH-LIKE PROTEIN 3, SERINE/THREONINE-PROTEIN KINASE WNK4, SULFATE ION, ... (6 entities in total)
Functional Keywords	signaling protein-transferase complex, klhl3, ubiquitin, adaptor protein, protein-binding, kelch repeat, wnk signalling pathway, signaling protein/transferase
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	66160.69
Authors	Sorrell, F.J.,Schumacher, F.R.,Kurz, T.,Alessi, D.R.,Newman, J.,Goubin, S.,Chalk, R.,Kopec, J.,Tallant, C.,Williams, E.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2013-11-29, release date: 2014-01-08, Last modification date: 2023-12-20)
Primary citation	Schumacher, F.,Sorrell, F.J.,Alessi, D.R.,Bullock, A.N.,Kurz, T. Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation. Biochem.J., 460:237-, 2014 Cited by PubMed: 24641320 DOI: 10.1042/BJ20140153 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation