4CFK

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY294002

Summary for 4CFK

• Entry DOI: 10.2210/pdb4cfk/pdb
• Related: 4CFL
• Descriptor: BRD4 PROTEIN, GLYCEROL, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE, ... (5 entities in total)
• Functional Keywords: cell cycle, inhibitor, histone, epigenetic reader, antagonist
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 15560.88

Authors

Chung, C.,Dittmann, A.,Drewes, G. (deposition date: 2013-11-18, release date: 2014-01-15, Last modification date: 2019-05-15)

• Primary citation: Dittmann, A.,Werner, T.,Chung, C.,Savitski, M.M.,Falth Savitski, M.,Grandi, P.,Hopf, C.,Lindon, M.,Neubauer, G.,Prinjha, R.K.,Bantscheff, M.,Drewes, G.; The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains.; Acs Chem.Biol., 9:495-, 2014; PubMed: 24533473; DOI: 10.1021/CB400789E

Experimental method

X-RAY DIFFRACTION (1.55 Å)