4CET

Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with dicoumarol at 2.2 A resolution

Summary for 4CET

Entry DOI	10.2210/pdb4cet/pdb
Descriptor	NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], ... (4 entities in total)
Functional Keywords	coumarin-based inhibitors, nq01, fad, flavoprotein, nad, nadp, nadph, oxidoreductase, oxidoreductase-inhibitor complex, single amino acid exchange, p187s
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P15559
Total number of polymer chains	1
Total formula weight	34190.78
Authors	Lienhart, W.D.,Gudipati, V.,Uhl, M.K.,Binter, A.,Pulido, S.,Saf, R.,Zangger, K.,Gruber, K.,Macheroux, P. (deposition date: 2013-11-12, release date: 2014-08-27, Last modification date: 2023-12-20)
Primary citation	Lienhart, W.-D.,Gudipati, V.,Uhl, M.K.,Binter, A.,Pulido, S.,Saf, R.,Zangger, K.,Gruber, K.,Macheroux, P. Collapse of the Native Structure by a Single Amino Acid Exchange in Human Nad(P)H:Quinone Oxidoreductase (Nqo1). FEBS J., 281:4691-, 2014 Cited by PubMed: 25143260 DOI: 10.1111/FEBS.12975 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation