4C61

Inhibitors of Jak2 Kinase domain

Summary for 4C61

Entry DOI	10.2210/pdb4c61/pdb
Related	4C62
Descriptor	TYROSINE-PROTEIN KINASE JAK2, N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-N4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine, ACETATE ION, ... (4 entities in total)
Functional Keywords	kinase, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains	2
Total formula weight	71137.63
Authors	Read, J.A.,Green, I.,Pollard, H.,Howard, T. (deposition date: 2013-09-17, release date: 2014-01-08, Last modification date: 2023-12-20)
Primary citation	Su, Q.,Ioannidis, S.,Chuaqui, C.,Almeida, L.,Alimzhanov, M.,Bebernitz, G.,Bell, K.,Block, M.,Howard, T.,Huang, S.,Huszar, D.,Read, J.A.,Rivard Costa, C.,Shi, J.,Su, M.,Ye, M.,Zinda, M. Discovery of 1-Methyl-1H-Imidazole Derivatives as Potent Jak2 Inhibitors. J.Med.Chem., 57:144-, 2014 Cited by PubMed: 24359159 DOI: 10.1021/JM401546N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation