4C2V

Aurora B kinase in complex with the specific inhibitor Barasertib

Summary for 4C2V

• Entry DOI: 10.2210/pdb4c2v/pdb
• Related: 4C2W
• Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, 2-[5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-3-yl]-N-(3-fluorophenyl)ethanamide, ... (4 entities in total)
• Functional Keywords: transferase-cell cycle complex, azd1152, transferase/cell cycle
• Biological source: XENOPUS LAEVIS (AFRICAN CLAWED FROG); More
• Cellular location: Nucleus: Q6DE08; Chromosome, centromere: O13024
• Total number of polymer chains: 4
• Total formula weight: 78464.47

Authors

Sessa, F.,Villa, F. (deposition date: 2013-08-20, release date: 2014-02-26, Last modification date: 2014-03-19)

• Primary citation: Sessa, F.,Villa, F.; Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism; Acta Crystallogr.,Sect.F, 70:294-, 2014; PubMed: 24598913; DOI: 10.1107/S2053230X14002118

Experimental method

X-RAY DIFFRACTION (1.49 Å)