4C16

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonist

Summary for 4C16

Entry DOI	10.2210/pdb4c16/pdb
Related	4C17
Descriptor	E-SELECTIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (8 entities in total)
Functional Keywords	cell adhesion, cell-adhesion molecule, c-type lectin, inflammation, leukocyte, glycomimetic, antagonist, catch- bond
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane ; Single-pass type I membrane protein: P16581
Total number of polymer chains	2
Total formula weight	67082.03
Authors	Preston, R.C.,Jakob, R.P.,Binder, F.P.C.,Sager, C.P.,Ernst, B.,Maier, T. (deposition date: 2013-08-09, release date: 2014-08-20, Last modification date: 2023-12-20)
Primary citation	Preston, R.C.,Jakob, R.P.,Binder, F.P.,Sager, C.P.,Ernst, B.,Maier, T. E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation. J.Mol.Cell.Biol., 8:62-, 2016 Cited by PubMed: 26117840 DOI: 10.1093/JMCB/MJV046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation