4BZC

Crystal structure of the tetrameric dGTP-bound wild type SAMHD1 catalytic core

Summary for 4BZC

Entry DOI	10.2210/pdb4bzc/pdb
Related	4BZB
Descriptor	DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	hydrolase, hiv restriction factor, dntpase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: Q9Y3Z3
Total number of polymer chains	4
Total formula weight	260229.22
Authors	Ji, X.,Yang, H.,Wu, Y.,Yan, J.,Mehrens, J.,DeLucia, M.,Hao, C.,Gronenborn, A.M.,Skowronski, J.,Ahn, J.,Xiong, Y. (deposition date: 2013-07-25, release date: 2013-10-23, Last modification date: 2023-12-20)
Primary citation	Ji, X.,Wu, Y.,Yan, J.,Mehrens, J.,Yang, H.,Delucia, M.,Hao, C.,Gronenborn, A.M.,Skowronski, J.,Ahn, J.,Xiong, Y. Mechanism of Allosteric Activation of Samhd1 by Dgtp Nat.Struct.Mol.Biol., 20:1304-, 2013 Cited by PubMed: 24141705 DOI: 10.1038/NSMB.2692 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.88 Å)

Structure validation