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4BZ8

Crystal structure of Schistosoma mansoni HDAC8 complexed with J1038

Summary for 4BZ8
Entry DOI10.2210/pdb4bz8/pdb
Related4BZ5 4BZ6 4BZ7 4BZ9
DescriptorHISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywordshydrolase, platyhelminths, hdac8, inhibitor
Biological sourceSCHISTOSOMA MANSONI
Total number of polymer chains4
Total formula weight203306.97
Authors
Marek, M.,Romier, C. (deposition date: 2013-07-24, release date: 2013-08-14, Last modification date: 2023-12-20)
Primary citationMarek, M.,Kannan, S.,Hauser, A.,Moraes Mourao, M.,Caby, S.,Cura, V.,Stolfa, D.A.,Schmidtkunz, K.,Lancelot, J.,Andrade, L.,Renaud, J.,Oliveira, G.,Sippl, W.,Jung, M.,Cavarelli, J.,Pierce, R.J.,Romier, C.
Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
Plos Pathog., 9:03645-, 2013
Cited by
PubMed: 24086136
DOI: 10.1371/JOURNAL.PPAT.1003645
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.21 Å)
Structure validation

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