4BZ6

Crystal structure of Schistosoma mansoni HDAC8 complexed with SAHA

Summary for 4BZ6

• Entry DOI: 10.2210/pdb4bz6/pdb
• Related: 4BZ5 4BZ7 4BZ8 4BZ9
• Descriptor: HISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ... (7 entities in total)
• Functional Keywords: hydrolase, platyhelminths, inhibition
• Biological source: SCHISTOSOMA MANSONI
• Total number of polymer chains: 4
• Total formula weight: 203998.86

Authors

Marek, M.,Romier, C. (deposition date: 2013-07-24, release date: 2013-08-14, Last modification date: 2023-12-20)

• Primary citation: Marek, M.,Kannan, S.,Hauser, A.,Moraes Mourao, M.,Caby, S.,Cura, V.,Stolfa, D.A.,Schmidtkunz, K.,Lancelot, J.,Andrade, L.,Renaud, J.,Oliveira, G.,Sippl, W.,Jung, M.,Cavarelli, J.,Pierce, R.J.,Romier, C.; Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.; Plos Pathog., 9:03645-, 2013; PubMed: 24086136; DOI: 10.1371/JOURNAL.PPAT.1003645

Experimental method

X-RAY DIFFRACTION (2 Å)