4BSR

Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form

Summary for 4BSR

• Entry DOI: 10.2210/pdb4bsr/pdb
• Related: 4BSO 4BSP 4BSS 4BST 4BSU
• Descriptor: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, R-SPONDIN-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: signaling protein, adult stem cell, leucine-rich repeat g-protein coupled receptor, leucine-rich repeat, furin domain, wnt signaling, congenital anonychia
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 4
• Total formula weight: 150227.43

Authors

Peng, W.C.,de Lau, W.,Forneris, F.,Granneman, J.C.M.,Huch, M.,Clevers, H.,Gros, P. (deposition date: 2013-06-11, release date: 2013-06-19, Last modification date: 2020-07-29)

• Primary citation: Peng, W.C.,De Lau, W.,Forneris, F.,Granneman, J.C.M.,Huch, M.,Clevers, H.,Gros, P.; Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.; Cell Rep., 3:1885-, 2013; PubMed: 23809763; DOI: 10.1016/J.CELREP.2013.06.009

Experimental method

X-RAY DIFFRACTION (3.2 Å)