4BS4

Crystal structure of human tankyrase 2 in complex with 4'-isopropylflavone

Summary for 4BS4

• Entry DOI: 10.2210/pdb4bs4/pdb
• Descriptor: TANKYRASE-2, ZINC ION, SULFATE ION, ... (7 entities in total)
• Functional Keywords: transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 55947.57

Authors

Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2013-06-07, release date: 2013-10-30, Last modification date: 2019-02-06)

• Primary citation: Narwal, M.,Koivunen, J.,Haikarainen, T.,Obaji, E.,Legala, O.E.,Venkannagari, H.,Joensuu, P.,Pihlajaniemi, T.,Lehtio, L.; Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity.; J.Med.Chem., 56:7880-, 2013; PubMed: 24116873; DOI: 10.1021/JM401463Y

Experimental method

X-RAY DIFFRACTION (1.89 Å)