4BKL

Crystal structure of the arthritogenic antibody M2139 (Fab fragment) in complex with the triple-helical J1 peptide

Summary for 4BKL

Entry DOI	10.2210/pdb4bkl/pdb
Descriptor	M2139 FAB FRAGMENT HEAVY CHAIN, M2139 FAB FRAGMENT LIGHT CHAIN, J1 EPITOPE (3 entities in total)
Functional Keywords	immune system, antibody, rheumatoid arthritis, collagen type ii
Biological source	MUS MUSCULUS (HOUSE MOUSE) More
Total number of polymer chains	5
Total formula weight	58596.88
Authors	Raposo, B.,Dobritzsch, D.,Ge, C.,Ekman, D.,Lindh, I.,Foerster, M.,Uysal, H.,Schneider, G.,Holmdahl, R. (deposition date: 2013-04-26, release date: 2014-02-05, Last modification date: 2023-12-20)
Primary citation	Raposo, B.,Dobritzsch, D.,Ge, C.,Ekman, D.,Xu, B.,Lindh, I.,Forster, M.,Uysal, H.,Nandakumar, K.S.,Schneider, G.,Holmdahl, R. Epitope-Specific Antibody Response is Controlled by Immunoglobulin Vh Polymorphisms. J.Exp.Med., 211:405-, 2014 Cited by PubMed: 24534192 DOI: 10.1084/JEM.20130968 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation