4BJX

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)

Summary for 4BJX

Entry DOI	10.2210/pdb4bjx/pdb
Descriptor	BROMODOMAIN-CONTAINING PROTEIN 4, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid (3 entities in total)
Functional Keywords	dna binding protein, inhibitor, histone, epigenetic reader
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	18374.40
Authors	Chung, C. (deposition date: 2013-04-20, release date: 2013-10-02, Last modification date: 2019-05-15)
Primary citation	Wyce, A.,Ganji, G.,Smitheman, K.N.,Chung, C.,Korenchuk, S.,Bai, Y.,Barbash, O.,Le, B.,Craggs, P.D.,Mccabe, M.T.,Kennedy-Wilson, K.M.,Sanchez, L.V.,Gosmini, R.L.,Parr, N.,Mchugh, C.F.,Dhanak, D.,Prinjha, R.K.,Auger, K.R.,Tummino, P.J. Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models. Plos One, 8:72967-, 2013 Cited by PubMed: 24009722 DOI: 10.1371/JOURNAL.PONE.0072967 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation