4BIS

JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

Summary for 4BIS

• Entry DOI: 10.2210/pdb4bis/pdb
• Related: 3NJY 4BIO
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase, non-heme, 2-oxoglutarate, dioxygenase, oxygenase, facial triad, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 89442.08

Authors

Chowdhury, R.,Thinnes, C.,Schofield, C.J. (deposition date: 2013-04-12, release date: 2014-02-05, Last modification date: 2023-12-20)

• Primary citation: Hopkinson, R.J.,Tumber, A.,Yapp, C.,Chowdhury, R.,Aik, W.,Che, K.H.,Li, X.S.,Kristensen, J.B.L.,King, O.N.F.,Chan, M.C.,Yeoh, K.K.,Choi, H.,Walport, L.J.,Thinnes, C.C.,Bush, J.T.,Lejeune, C.,Rydzik, A.M.,Rose, N.R.,Bagg, E.A.,McDonough, M.A.,Krojer, T.,Yue, W.W.,Ng, S.S.,Olsen, L.,Brennan, P.E.,Oppermann, U.,Muller-Knapp, S.,Klose, R.J.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.; 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.; Chem Sci, 4:3110-3117, 2013; PubMed: 26682036; DOI: 10.1039/C3SC51122G

Experimental method

X-RAY DIFFRACTION (2.493 Å)