4BHN

Crystal Structures of Ask1-inhibitor Complexes

Summary for 4BHN

• Entry DOI: 10.2210/pdb4bhn/pdb
• Related: 4BF2 4BIB 4BIC 4BID 4BIE
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5, 4-tert-butyl-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: transferase, structure based design
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: Q99683
• Total number of polymer chains: 2
• Total formula weight: 75939.94

Authors

Singh, O.,Shillings, A.,Craggs, P.,Wall, I.,Rowland, P.,Skarzynski, T.,Hobbs, C.I.,Hardwick, P.,Tanner, R.,Blunt, M.,Witty, D.R.,Smith, K.J. (deposition date: 2013-04-04, release date: 2013-07-03, Last modification date: 2023-12-20)

• Primary citation: Singh, O.,Shillings, A.,Craggs, P.,Wall, I.,Rowland, P.,Skarzynski, T.,Hobbs, C.I.,Hardwick, P.,Tanner, R.,Blunt, M.,Witty, D.R.,Smith, K.J.; Crystal Structures of Ask1-Inhibtor Complexes Provide a Platform for Structure Based Drug Design.; Protein Sci., 22:1071-, 2013; PubMed: 23776076; DOI: 10.1002/PRO.2298

Experimental method

X-RAY DIFFRACTION (2.3 Å)