4BDT

Human acetylcholinesterase in complex with huprine W and fasciculin 2

Summary for 4BDT

Entry DOI	10.2210/pdb4bdt/pdb
Related	1B41 1F8U 1FSC 1FSS 1KU6 1MAH 1PUV 1PUW 1VZJ 2CLJ 2X8B 4BDS
Descriptor	ACETYLCHOLINESTERASE, FASCICULIN-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	hydrolase-inhibitor complex, butyrylcholinesterase, nerve transmission, inhibition, alpha-beta hydrolase, hydrolase/inhibitor
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	72746.45
Authors	Nachon, F.,Carletti, E.,Ronco, C.,Trovaslet, M.,Nicolet, Y.,Jean, L.,Renard, P.-Y. (deposition date: 2012-10-06, release date: 2013-05-29, Last modification date: 2023-12-20)
Primary citation	Nachon, F.,Carletti, E.,Ronco, C.,Trovaslet, M.,Nicolet, Y.,Jean, L.,Renard, P.Y. Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. Biochem. J., 453:393-399, 2013 Cited by PubMed: 23679855 DOI: 10.1042/BJ20130013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.104 Å)

Structure validation