4BCR

Structure of PPARalpha in complex with WY14643

Summary for 4BCR

• Entry DOI: 10.2210/pdb4bcr/pdb
• Related: 1I7G 1K7L 1KKQ
• Descriptor: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA, 1,2-ETHANEDIOL, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, ... (4 entities in total)
• Functional Keywords: transcription, nuclear receptor, ppar, fibrate
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: Q07869
• Total number of polymer chains: 2
• Total formula weight: 63451.59

Authors

Bernardes, A.,Muniz, J.R.C.,Polikarpov, I. (deposition date: 2012-10-02, release date: 2013-05-29, Last modification date: 2013-08-07)

• Primary citation: Bernardes, A.,T Souza, P.C.,Muniz, J.R.C.,Ricci, C.G.,Ayers, S.D.,Parekh, N.M.,Godoy, A.S.,Trivella, D.B.B.,Reinach, P.,Webb, P.,Skaf, M.S.,Polikarpov, I.; Molecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization; J.Mol.Biol., 425:2878-, 2013; PubMed: 23707408; DOI: 10.1016/J.JMB.2013.05.010

Experimental method

X-RAY DIFFRACTION (2.497 Å)