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4BCF

Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Summary for 4BCF
Entry DOI10.2210/pdb4bcf/pdb
Related1PF6 4BCG 4BCH 4BCI 4BCJ 4BCK 4BCM 4BCN 4BCO 4BCP 4BCQ
DescriptorCYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ... (4 entities in total)
Functional Keywordstransferase-cell cycle complex, cdk-cyclin complex, transcription-protein binding, structure-based drug design, transferase/cell cycle
Biological sourceHOMO SAPIENS (HUMAN)
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Total number of polymer chains2
Total formula weight68650.10
Authors
Hole, A.J.,Baumli, S.,Wang, S.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2012-10-02, release date: 2013-01-09, Last modification date: 2019-05-22)
Primary citationHole, A.J.,Baumli, S.,Shao, H.,Shi, S.,Pepper, C.,Fischer, P.M.,Wang, S.,Endicott, J.A.,Noble, M.E.M.
Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56:660-, 2013
Cited by
PubMed: 23252711
DOI: 10.1021/JM301495V
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.011 Å)
Structure validation

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