4B95

pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound

Summary for 4B95

• Entry DOI: 10.2210/pdb4b95/pdb
• Related: 1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B9K
• Descriptor: TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, ... (6 entities in total)
• Functional Keywords: transcription, hypoxia inducible factor, hif-1alpha inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : Q15370 Q15369; Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
• Total number of polymer chains: 12
• Total formula weight: 172930.85

Authors

Buckley, D.L.,Gustafson, J.L.,VanMolle, I.,Roth, A.G.,SeopTae, H.,Gareiss, P.C.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M. (deposition date: 2012-08-31, release date: 2012-10-24, Last modification date: 2017-08-23)

• Primary citation: Buckley, D.L.,Gustafson, J.L.,Van Molle, I.,Roth, A.G.,Tae, H.S.,Gareiss, P.C.,Jorgensen, W.L.,Ciulli, A.,Crews, C.M.; Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1Alpha; Angew.Chem.Int.Ed.Engl., 51:11463-, 2012; PubMed: 23065727; DOI: 10.1002/ANIE.201206231

Experimental method

X-RAY DIFFRACTION (2.8 Å)