4B7J

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Summary for 4B7J

Entry DOI	10.2210/pdb4b7j/pdb
Related	4B7M 4B7N 4B7Q 4B7R
Descriptor	NEURAMINIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, neuraminidase inhibitor, nai, nais, oseltamivir, zanamivir, antiviral resistance, immunocompromised, h275y
Biological source	INFLUENZA A VIRUS (INFLUENZA A VIRUS)
Total number of polymer chains	1
Total formula weight	52686.76
Authors	van der Vries, E.,Vachieri, S.G.,Xiong, X.,Liu, J.,Collins, P.J.,Walker, P.A.,Haire, L.F.,Hay, A.J.,Schutten, M.,Osterhaus, A.D.M.E.,Martin, S.R.,Boucher, C.A.B.,Skehel, J.J.,Gamblin, S.J. (deposition date: 2012-08-20, release date: 2012-10-03, Last modification date: 2020-07-29)
Primary citation	Van Der Vries, E.,Collins, P.J.,Vachieri, S.G.,Xiong, X.,Liu, J.,Walker, P.A.,Haire, L.F.,Hay, A.J.,Schutten, M.,Osterhaus, A.D.M.E.,Martin, S.R.,Boucher, C.A.B.,Skehel, J.J.,Gamblin, S.J. H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis Plos Pathog., 8:2914-, 2012 Cited by PubMed: 23028314 DOI: 10.1371/JOURNAL.PPAT.1002914 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.417 Å)

Structure validation