4B6C
Structure of the M. smegmatis GyrB ATPase domain in complex with an aminopyrazinamide
Summary for 4B6C
| Entry DOI | 10.2210/pdb4b6c/pdb |
| Descriptor | DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit B, 6-(3,4-dimethylphenyl)-3-[[4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]amino]pyrazine-2-carboxamide, SODIUM ION, ... (4 entities in total) |
| Functional Keywords | isomerase, dna topoisomerase, inhibitor |
| Biological source | Mycobacterium smegmatis More |
| Total number of polymer chains | 2 |
| Total formula weight | 44982.65 |
| Authors | Tucker, J.A.,Shirude, P.S.,Madhavapeddi, P.,Hussein, S.,Basu, R.,Ghorpade, S. (deposition date: 2012-08-09, release date: 2013-01-23, Last modification date: 2018-11-28) |
| Primary citation | Shirude, P.S.,Madhavapeddi, P.,Tucker, J.A.,Murugan, K.,Patil, V.,Basavarajappa, H.,Raichurkar, A.V.,Humnabadkar, V.,Hussein, S.,Sharma, S.,Ramya, V.K.,Narayan, C.B.,Balganesh, T.S.,Sambandamurthy, V.K. Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis. ACS Chem. Biol., 8:519-523, 2013 Cited by PubMed: 23268609DOI: 10.1021/cb300510w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report
