4B53

Crystal structure of the isolated IgG4 CH3 domain

Summary for 4B53

Entry DOI	10.2210/pdb4b53/pdb
Related	1ADQ 4B51
Descriptor	IG GAMMA-4 CHAIN C REGION, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	immune system, antibody, immunoglobulin, fab arm exchange, igg1
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	25044.77
Authors	Davies, A.M.,Rispens, T.,den Bleker, T.H.,McDonnell, J.M.,Gould, H.J.,Aalberse, R.C.,Sutton, B.J. (deposition date: 2012-08-02, release date: 2012-12-05, Last modification date: 2023-12-20)
Primary citation	Davies, A.M.,Rispens, T.,Den Bleker, T.H.,Mcdonnell, J.M.,Gould, H.J.,Aalberse, R.C.,Sutton, B.J. Crystal Structure of the Human Igg4 C(H)3 Dimer Reveals the Role of Arg409 in the Mechanism of Fab-Arm Exchange. Mol.Immunol., 54:1-, 2012 Cited by PubMed: 23164605 DOI: 10.1016/J.MOLIMM.2012.10.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation